WebMay 15, 2024 · Indeed, several regions near key B cell activation genes, such as Pou2f2 (encodes Oct-2), Cd86, Nfatc1 Ebf1, and Il10ra, failed to acquire DNA methylation at CpGs that coincided with increased ... WebCertain CpG motifs (CpG-A) are especially potent at activating NK cells and inducing IFN-α production by PDCs, while other motifs (CpG-B) are especially potent B cell activators. …
Maintenance of Serological Memory by Polyclonal Activation of …
WebJul 24, 2008 · Background Human B cells and plasmacytoid dendritic cells (pDC) are the only cells known to express both TLR7 and TLR9. Plasmacytoid dendritic cells are the primary IFN-α producing cells in response to TLR7 and TLR9 agonists. The direct effects of TLR7 stimulation on human B cells is less understood. The objective of this study was to … WebOct 1, 2003 · CpG-containing oligodeoxynucleotides (CpG ODNs) act on Toll-like receptor 9 (TLR9) that is expressed on B cells and plasmacytoid dendritic cells (pDCs) to stimulate … contact names with emojis
National Center for Biotechnology Information
WebNov 1, 2016 · However, in vitro activation with CD40L (with or without anti-Ig and CpG) changed slightly the expression of CD27 on B cells … WebBackground/MethodsFor mechanistic studies, in-vitro human B-cell differentiation and generation of plasma cells are invaluable techniques. However, the heterogeneity of both T-cell-dependent (TD) and T-cell-independent (TI) stimuli and the disparity of culture conditions used in existing protocols make the interpretation of results challenging. The … WebAug 3, 1999 · CpG DNA is as potent as the complete Freund’s adjuvant regarding the induction of B cell and T cell responses, but it is less toxic and it induces a T helper 1 (Th1) response ( 2, 3 ). Alum, the adjuvant that is used routinely in human vaccination, induces the less favorable Th2 response. CpG is more effective than alum, and the combination ... contact name won\u0027t change android