WebThe cullin family proteins are scaffold proteins for the Ring finger type E3 ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Humans express seven cullin proeins: CUL1-3, CUL4A, CUL4B, CUL5, and CUL7. Each cullin protein can form an E3 ligase similar to the prototype Ring-type E3 ligase Skp1-CUL1-F-box complex. WebNov 16, 2024 · Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment ...
Calpain activity is negatively regulated by a KCTD7–Cullin-3 …
WebThe E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit … WebAnti-Cullin 3 antibody produced in rabbit (Anti-CUL3); ~ 1.0mg/mL, affinity isolated antibody, buffered aqueous solution; Suitable for indirect immunofluorescence; Cullin 3 … how do you abbreviate installment
Anti-Cullin 3/CUL3 Antibody - Bosterbio
WebAnti-Cullin 3/CUL-3 antibody See all Cullin 3/CUL-3 primary antibodies Description Rabbit polyclonal to Cullin 3/CUL-3 Host species Rabbit Tested applications Suitable for: IHC-P more details Species reactivity Reacts with: Human Predicted to … WebNEDD8 Antibody detects endogenous levels of total NEDD8. RRID: AB_2838263 引用格式: Affinity Biosciences Cat# DF6297, RRID:AB_2838263. ... is also required for neddylation of the cullin proteins (6). Protein de-neddylation is catalyzed by a number of enzymes in the cell, including a ubiquitin-specific protease USP21, the NEDP1/DEN1 ... WebCullin-3 belongs to the cullin family of hydrophobic proteins that confer substrate specificity to the multimeric Cullin-RING E3 ubiquitin ligase (CRL) complexes by acting as scaffold … how do you abbreviate infrastructure