WebNov 1, 2024 · Author summary The spleen, the largest secondary lymphoid organ in humans, not only fulfils a broad range of immune functions, but also plays an important role in red blood cell (RBC) life cycle. In this study, we perform a computational study to simulate the passage of RBCs through interendothelial slits (IES) in the spleen at different stages … Websplenic artery & vein -enter/ exit at splenic hilum -splenic artery branches into small vessels -veins small until hilum -WITHIN spleen, arterial capillaries anastomose (join) w/venous sinus -RBC's passing through are filtered Spleen size highly variable in size < 12.0 cm LONG (Sup to Inf) < 7.0 cm WIDTH (Med to Lat) < 5.0 cm DEPTH (thickness)
Normal Functions of the Spleen Relative to Red Blood …
WebFunctions of the Spleen? 1. defense against disease 2. hematopoiesis (all blood cells)/ erythropoiesis (rbcs) 3. destruction and removal of flawed red blood cells and platelets (culling & pitting) 4. blood reservoir 5. storage of iron Erythropoiesis primarily occurs in? embryologic gestation; spleen develops around 5th week gestation WebStudy with Quizlet and memorize flashcards containing terms like -production of lymphocytes and plasma cells -production of antibodies -storage of iron -storage of other metabolites, -maturation of the surface of erythrocytes -reservoir -culling -pitting -disposal of senescent or abnormal erythrocytes -functions related to platelet and leukocyte life … list of all integrated care systems
The spleen as a hematological organ - ScienceDirect
Webspleen plays an important role in the selective removal of abnormal cells (spherocytes, poikilocytes) and intracellular inclusions (Heinz bodies, HJ bodies) functions are known … WebPitting: In addition to executing the culling function, open microcirculation in the spleen also carries out the pitting function. Pitting refers to the elimination of intraerythrocytic inclusions without causing damage to the red blood cells. Narrow slits of the sinus are used in the pitting function. Removal of Howell Jolly Bodies: WebAug 27, 2016 · Splenic filtration involves three processes: culling, pitting, and erythroclasis. • Culling refers to the destruction of erythrocytes, or other circulating blood cells, physiologically as they age or in pathologic … images of inhaling