The α-d-phosphohexomutase (PHM) superfamily is traditionally divided into four major subgroups, the PGMs with specificity for α-d-glucose 1- or 6-phosphate, the PMM/PGMs with dual specificity for α-d-glucose and α-d-mannose phosphosugars, and the phosphoglucosamine mutases and N-acetylglycosamine … See more The human PGM1 gene has two main biologically relevant isoforms resulting from alternative splicing and the use of two alternative promoters and 5′ exons, exons 1-1 and 1-2 in isoforms 1 and 2, respectively, together … See more The crystal structure of the isoform 2 variant of human PGM1 was determined, and is reported here for the first time. The structure was solved both for the free holoenzyme form and in complex with substrate (G1P) and … See more PGM1-2 substrate and product complexes were generated by soaking crystals with G1P and G6P, respectively. We here publish, for the first … See more The additional residues at the PGM1-2 N-terminus form a short α-helix that protrudes from D1 in the crystal structure (Fig. 2b). There is … See more WebApr 28, 2024 · （12）Role of two phosphohexomutase genes in glycogen synthesis in Synechocystis sp. PCC6803,Chinese Science Bulletin,2013,第11作者 （13）Molecular cloning and functional analyses of glutathione peroxidase homologous genes from Chlorella sp.,Gene,2012,第11作者
Assessment and Impacts of Phosphorylation on Protein …
WebDec 27, 1995 · Carbohydrate-deficient glycoprotein (CDG) syndromes are genetic … WebDec 3, 2024 · Phosphoglucomutase 5 (PGM5) in humans is known as a structural muscle … crypt the game
Phosphoglucomutase - an overview ScienceDirect Topics
WebJan 1, 2024 · Enzymes in the α-d-phosphohexomutase (PHM) superfamily catalyze a multistep reaction, entailing two successive phosphoryl transfers. Key to this reaction is a conserved phosphoserine in the active site, which serves alternately as a phosphoryl donor and acceptor during the catalytic cycle. In addition to its role in the enzyme mechanism, … WebJan 1, 2009 · The α-D-phosphohexomutase enzyme superfamily is widespread and diverse. Two related and well-characterized proteins make up the majority of the family: the highly specific PGM, which only uses glucose as a substrate, and the less specific PMM/PGM, which can use either glucose or mannose. Two other enzymes, PNGM and PAGM, are … WebFeb 1, 2024 · Most enzymes in the α-D-phosphohexomutase superfamily catalyze the reversible conversion of 1- to 6-phosphosugars. They play important roles in carbohydrate and sugar nucleotide metabolism, and participate in the biosynthesis of polysaccharides, glycolipids, and other exoproducts. Mutations in genes encoding these enzymes are … cryptofraud secretservice.gov