Webb13 apr. 2024 · At the functional level, depletion of SVIL and SHANK3 inhibited megakaryopoiesis and thrombopoiesis (Supplementary Fig. 4g–i), while overexpression of SVIL rescued the inhibitory effect of ... Webb31 aug. 2024 · SH3 and multiple ankyrin repeat domain 3 ( SHANK3 ), also known as proline-rich synapse-associated protein 2 ( ProSAP2 ), is a gene that encodes excitatory synaptic core scaffolding proteins that organize the macromolecular protein complex of the postsynaptic density (PSD) ( Naisbitt et al., 1999; Sheng and Kim, 2000 ).
Postsynaptic Shank Antagonizes Dendrite Branching Induced by …
Webb16 nov. 2015 · These miRNAs regulated the expression of SHANK3 and other genes encoding actin-related proteins that interact with Shank3, through direct binding sites in the 3′ untranslated region (UTR). Moreover, overexpression or inhibition of miR-7 and miR-504 affected the dendritic spines of the cultured hippocampal neurons in a Shank3 … Webb13 apr. 2024 · The expression of SHANK1 is upregulated in non-small cell lung cancer (NSCLC), and is correlated with clinic pathological characteristics of NSCLC, revealing an important oncogenic role and mechanism of SHank1 and suggestingSHANK1 can be a potential therapeutic target in NSCLCs. PDF References SHOWING 1-10 OF 43 … danish delights dunedin
SHANK3 SH3 and multiple ankyrin repeat domains 3 [ (human)]
WebbSHANK3. SH3 and multiple ankyrin repeat domains 3 (Shank3), also known as proline-rich synapse-associated protein 2 (ProSAP2), is a protein that in humans is encoded by the … Webb6 jan. 2016 · tion of the SHANK3 gene was found in patients diagnosed with bipolar disorders and mice with Shank3 overexpression exhibit synaptic dysfunction and manic-like phenotypes (Han et al., 2013). Interestingly, a non-sense mutation of SHANK3 changing an arginine to stop codon (R1117X) was identified from three Webb5 jan. 2014 · The Shank family of scaffolding proteins (also known as ProSAP, cortBP, SSTRIP, Synamon and Spank) consists of three major isoforms—Shank1, Shank2 and Shank3—all of which are present in the brain, though … danish delight recipes